Kennisregio aan Zee (Knowledge Region by the Sea) is a collaborative initiative. The Hague, Leiden, Delft, Zoetermeer, the provincial administration, and key local knowledge institutions are brought together to tackle the critical spatial-economic challenges that the region will face in the future. The current spatial constraints in this region require an integrated approach and vision formation to provide spatial solutions for this densely populated region. To address the major spatial and landscape challenges for the coming decades, we proposed a strategy “Kennisregio aan Zee 2070: A landscape-based approach.”